Tuberculosis-HIV co-infection

Tuberculosis is an opportunistic infection and is easily affected to the people with HIV. HIV weakens the immune system which increases chance of getting affected with tuberculosis. Person have both HIV/tuberculosis is referred as HIV-tuberculosis co-infection. Conditions become severe in the case of multi drug resistance tuberculosis and extensively drug resistance tuberculosis is difficult to cure and causes increase in mortality. Pro inflammatory cytokine production by tuberculous granulomas is connected with HIV viremia which leads to the cause of disease. Untreated latent TB infection can be easily activated to TB disease in HIV patients due to their low immunity. If not treated it leads to death. TB is difficult to diagnose in HIV positive patient than a person with only TB.HIV-TB co-infection people are treated with anti-retro viral therapy and anti-tubercular drugs. Advantages of early anti- retro viral drugs includes decreased trend of mortality

 

  • Immune reconstitution inflammatory syndrome.
  • Pathogenesis of co-infection of HIV and tuberculosis
  • TB reactivation by HIV
  • Animal model studies
  • HIV/TB specific T/B cell response

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