Advancements in Tuberculosis and Lung Diseases

Drug discovery and development in TB

Fighting the global tuberculosis (TB) epidemic calls for the development of new, more potent antibiotics that inhibit Mycobacterium tuberculosis' critical proteins. The main goal of drug design and discovery is to identify a chemical that can specifically target a specific cavity in a protein and prevent it from engaging in its enzymatic function. A variety of studies, including clinical trials, are subsequently performed on the substance in question to determine how well it works to combat the infection inside the host. Recently, as opposed to the tedious and time-consuming old methods of drug design, new strategies that involve computational and analytical methodologies have improved the odds of drug discovery.
A new generation of software that is utilized to create and optimize active compounds that can be used in chemotherapeutic research in the future to tackle global tuberculosis resistance has improved computational methodologies in drug creation.