Funmilayo Grace Boni
Southwest University, China
Title: Cytokine storm in tuberculosis and IL-6 involvement
Biography
Biography: Funmilayo Grace Boni
Abstract
Statement of the Problem: Tuberculosis is probably the most seasoned illness of the humanity. Intricacies or subsequent death emerging from these infections are frequently connected with cytokine storm. Interleukin-6 (IL-6) plays a crucial role in the immune response to tuberculosis. Therefore, there is a need to research some new therapeutic approaches to block IL-6 signaling that are right now being applied to the M. tuberculosis. In this review, we investigate the implication of IL-6 in the context of tuberculosis research.
Methodology & Theoretical Orientation: Summary of studies demonstrating the implication of IL-6 in the inflammation. The recapitulation of the repurposing of anti-IL-6 therapeutics for TB.
Findings in this study: Cytokine storm in tuberculosis can be targeted via the JAK/STAT pathways. Therapeutic avenues dampening IL-6 can quell the storm.
Conclusion & Significance: An understanding of monocyte- and macrophage-mediated IL-6 release as part of the “cytokine storm” has played a role in a greater understanding of TB. IL-6 was identified as a major driver of disease severity in TB. TB patients should therefore be treated with anti-IL-6 therapeutics, as blunting IL-6 production may be advantageous in attenuating “cytokine storm” from TB. Researches on TB, are making tocilizumab and other anti IL-6 therapeutic approaches available to TB patients, who are believed to face an elevated mortality from complications of M. tuberculosis.